Release date: 2008-02-21 Effect of remifentanil on systemic circulation resistance in patients undergoing cardiopulmonary bypass The effect of systemic circulation resistance on remifentanil in lowering blood pressure was investigated by cardiopulmonary bypass. Methods Rheumatic heart disease was performed in 26 patients with mitral valve or aortic valve replacement, ASA class II or III, heart function class II or III, age 20 to 55 years old, randomly divided into 2 groups: The fentanyl group (R group) and the control group (group C), 13 cases in each group. After the heart stopped, the perfusion flow was maintained at 2.4L?min^-1?m^-2, moderately hypothermic cardiopulmonary bypass. The mean arterial pressure (MAP) and systemic circulation resistance (SVR) immediately before administration (T0, basal value) were recorded, and remifentanil 10 μg/kg (R group) or 20 ml of normal volume saline (20 ml) was injected through the venous end of the blood reservoir. Group C), MAP and SVR were recorded at 5 min (T5), 10 min (T10), and 15 min (T15) after administration. Blood was collected from the arterial end of the membrane oxygenator to determine histamine and nitric oxide (NO) in plasma. 6-keto-prostaglandin F1α (PGF1α) concentration. Results Compared with T0, MAP and SVR decreased in T group and R5 in group R, and MAP and SVR increased in group C at T5, 10, and 15 (P<0.05). Compared with group C, group R was T5, 10, and 15 hours. MAP and SVR were decreased (P<0.05). There was no significant difference between histamine and PGF1α concentrations and between groups (P>0.05). There was no MAP and histamine, NO and PGF1α concentrations in R group. Correlation (P>0.05). Conclusion The antihypertensive effect of remifentanil is associated with a decrease in SVR, and the change in SVR is not associated with NO and prostacyclin released by histamine and vascular endothelial cells in plasma. ——Midi Medical Network Wasabi Paste,Mustard Paste,Spicy Sushi Wasabi Paste,Hot Sushi Wasabi Paste NINGXIA KOFOLON INTERNATIONAL CO.,LTD. , https://www.kofolon.com