New compounds kill 80% of cancer cells July 20, 2016 Source: Noble Many cancer deaths are due to the resistance of cancer cells to chemotherapeutic drugs, which has also contributed to overcoming the development of this barrier. The latest research shows that the researchers found a new compound that kills multidrug-resistant mouse cancer cells. The group includes members from Navarre Pamplona, ​​Spain and the University of Krakow, Jagiellon Medical School, and their research results are published in the Journal of Bioorganic and Medicinal Chemistry. Dr. Enrique Domingos, the lead author of the university from Navarre and Jagiellon University, said: “Our research reports a new way to fight drug-resistant cancer. We know that there is more research to do, but we are happy to develop new possibilities, and we are grateful for these results.†The new study was produced in 57 compounds identified as having anti-cancer properties, and the team believes that some of them may enhance the efficacy of chemotherapy drugs. The focus of the research is the so-called "efflux pump", which develops a common defense mechanism for cancer cells exposed to chemotherapy. Located in the cell membrane, the efflux pump is a protein that excludes toxic compounds from cells, and one such protein is called ABCB1. Some compounds kill 80% of resistant cells The team wanted to see if the selenocompounds found in previous work blocked the ABCB1 efflux pump. Multidrug Resistance (MDR) Mouse T Lymphoma Cells After running various test tubes, the researchers found that these compounds were more effective at blocking efflux pumps than other compounds. They also found that these compounds can trigger cancer cell apoptosis and cell suicide. The most active selenocompounds kill about 80% of mouse cancer cells. They acknowledge that these results are only the beginning of a long process of developing a new drug, and the next step will be to perform live experiments on these compounds.
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