Release date: 2014-07-30 Beijing time on July 29th news, Science Daily reported that you have thought about the possibility that there is a virus in your internal organs, and this virus has not been detected by scientists in the past few decades? Researchers at San Diego State University in the United States have found that a new virus, called crAssphag, is found in more than half of the world's humans. This virus infects one of the most common visceral bacteria, the Bacteroidetes. This type of bacteria is said to be associated with obesity, diabetes and other visceral-related diseases. The study was published in the journal Nature Communications. Robert A. Edwards, a professor of bioinformatics at San Diego State University, and colleagues unexpectedly discovered the virus. At the time, they were working with the author of the study, Bas E. Dutilh, a visiting scholar at the University of Nemein Medical Center in the Netherlands, to find new ways to use the results of previous studies on parasitic visceral viruses. virus. From DNA samples extracted from the feces of 12 individuals, the researchers noted that all samples had a special group of viral DNA, which was approximately 97,000 base pairs. When Edwards and colleagues compared the findings to a detailed list of known viruses, they found nothing. The researchers then screened the virus from the National Institute of Health's Human Microbiome Program (HMP) database and the Argonne National Laboratory's MG-RAST database and found that they were abundant in human feces samples. To prove that the viral DNA found in their computer data does exist in nature, San Diego State University virologist John Mokili uses a method called DNA amplification in the National Health Study. The virus was found in the original sample of the database. "So we have biological evidence that the virus found in the computer data does exist in the sample." Mokiri said. Half of the people who sampled had this new type of virus, but scientists knew nothing about it. "It's not uncommon to find a new type of virus and find it, but it's rare that so many people have it, and it's really strange that no one has ever found it in the past," Edwards said. Ancient virus The widespread presence of this virus suggests that it may not be a young virus. "In every sample of people we tested, this virus almost always exists. As far as we know, this virus appears as long as humans," Edwards said. He and his team named the virus crAssphage, named after the cross-assembly software project used to discover the virus. Some proteins in the DNA of crAssphage are similar to proteins of other known viruses. This allowed Edwards' team to determine that the new virus they found was a phage that would infect and replicate inside the bacteria, and by using innovative bioinformatics techniques, researchers were able to predict that this phage would pass through a common infection. The visceral bacteria - the Bacteroidetes and the proliferation of proliferation. Bacteroides is living at the end of the human gut and they are suspected to play an important role in the link between gut bacteria and obesity. The role of crAssphage in this process will be a focus of future research. More details about crAssphage are currently difficult to obtain. How the virus spreads is still unknown. It does not appear in the stool samples of newborn babies. It indicates that the virus is not transmitted from mother to baby, but is infected in childhood. The composition of the viral DNA indicates that it is a circular structure, and further experimental work has confirmed that the viral DNA is a single entity, but it is difficult to separate it. "We know it's there, but we can't get it," Edwards said. Once the virus is isolated, Edwards hopes to study the role of the virus in obesity. This virus may regulate the activity of Bacteroides to some extent, but whether crAssphage promotes or inhibits the process related to diabetes in the viscera remains to be seen. This virus may be used to prevent or alleviate other diseases affected by the internal organs, such as diabetes and gastroenterology. Once scientists understand these processes, Edwards envisions one day a personalized medicine based on the virus. He said: "We will be able to isolate the special virus strain in your body, manipulate it to invade the germ, and return it to you." Source: Phoenix Technology
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