Sarm Aicar Acadesine Sarms Powder Acadesine Aicar

/ October 24, 2018

Model NO.: SARMs
Name of Sarms: Sarms Powder Acadesine Aicar
CAS No: CAS: 2627-69-2
Function: New Supplements for Gaining Mass Bodybuilding
MOQ: 1g
Payment: Escrow, Western Union, Paypal, Tt, L/C
Shipping Method: FedEx, DHL, EMS or by Sea
Delivery Time: Within 3days After Payment
Policy: Reshipping Policy
Appearance: Almost White or White Powder
Assay(HPLC): 99.59%
Trademark: General
Transport Package: Alumiuim Foil or as Customer′s Requirement
Specification: CQC GMP IS9001 CNAS SGS
Origin: Jiangsu, China(Mainland)
HS Code: 2937290090
Model NO.: SARMs
Name of Sarms: Sarms Powder Acadesine Aicar
CAS No: CAS: 2627-69-2
Function: New Supplements for Gaining Mass Bodybuilding
MOQ: 1g
Payment: Escrow, Western Union, Paypal, Tt, L/C
Shipping Method: FedEx, DHL, EMS or by Sea
Delivery Time: Within 3days After Payment
Policy: Reshipping Policy
Appearance: Almost White or White Powder
Assay(HPLC): 99.59%
Trademark: General
Transport Package: Alumiuim Foil or as Customer′s Requirement
Specification: CQC GMP IS9001 CNAS SGS
Origin: Jiangsu, China(Mainland)
HS Code: 2937290090
SARM Aicar Acadesine CAS 2627-69-2 Sarms Powder Acadesine Aicar

Aicar Details:

Name:Aicar
Synonyms:Acadesine;Aica-riboside;Ampk;5-aminoimidazole-4-carboxamide-1-beta-riboside;
5-aminoimidazole-4-carboxamide-1-b-d-ribofuranoside;Z-riboside
CAS: 2627-69-2
MF: C9H14N4O5
MW: 258.23
EINECS: 220-097-5
Chemical Properties:white or off-white solid
Assay:99%
Usage:glucose uptake stimulant; AMPK activator.AICAR is a nucleoside analogue that is able to enter nucleoside pools and is able to significantly increase levels of adenosine during periods of ATP breakdown. Adenosine-regulating agents (ARAs) hav e been recognized for therapeutic potential in myocardial ischemia. Cardioprotective.
Packing:foil bag or as required

Description:

AICAR is a peptide whose technical name is 5-Aminoimidazole-4-carboxamide ribonucleotide.  It can also be known as AICA ribonucleotide, ZMP, or Acadesine.  It is an intermediate contained in the generation of inosine monophosphate.  It primarily functions as an AMP-activated protein kinase agonist, meaning that it has the ability to promote the operation of nutrient stores for energy production.  It has a molecular mass of 338.211, and it has a molecular formula of C9H15N4O8P.

AICAR is an adenosine analog that selectively activates AMP-activated protein kinase (AMPK). AMPK regulates lipid and glucose metabolism to maintain cellular energy homeostasis (Hardie and Carling).

AICAR can play a hand in boosting these processes because it contains the ability to penetrate cardiac cells and block the production of enzymes tied to regulating glucose intake and energy expulsion.  With these regulatory enzymes inhibited, the affected cells can in turn boost the amount of glucose that can be received, and it can also increase its level of energy conversion.  Additionally, the peptide's presence has been determined to aid in lowering programmed cell death, a process that is also known as apoptosis.

Functions:

AICAR (AICA-Riboside) strongly inhibits the transcription of PPAR&alpha and the coactivation of PPAR&alpha. In adipocyte studies it has been shown to antagonize lipolysis induced by isoprenaline and has been suggested for use in kinase cascade research. Additionally, research indicates that AICAR blocks the differentiation of 3T3-L1 (sc-2243) adipocytes. Studies demonstrate that AICAR can mimic the activity of  (sc-211647) by activating AMPK (AMP-activated protein kinase), and affecting the expression of PEPCK-M (PEPCK) and glucose-6-phosphatase (G6Pase). The 5-aminoimidazole-4-carboxamide ribonucleoside (ZMP) is the monophosphorylated derivative of AICA-Riboside, and it can serve as the substrate for the aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC). AICAR is an inhibitor of Hsp90, mTOR and p70 S6 Kinase.

AMP-activated protein kinase (AMPK) functions as a metabolic sensor that regulates lipid and glucose metabolism to maintain cellular energy homeostasis and to protect against metabolic stress.AICAR is a selective activator of AMPK in both hepatocytes and adipocytes. At 0.5 mM it inhibits the synthesis of fatty acids and sterols and inactivates HMG-CoA reductase in rat hepatocytes.AICAR (0.5 mM) inhibits stimulated glucose uptake to 62% of controls and reduces GLUT4 translocation 2.5-fold in 3T3-L1 adipocytes. It also blocks the expression of pro-inflammatory cytokines (TNF-α/IL-1β and IL-6), iNOS, COX-2, and MnSOD genes in glial cells and macrophages by inhibiting NFκB and C/EBP pathways.

Biological Activity:

AICAR is a cell permeable activator of AMP-activated protein kinase (AMPK), a metabolic master regulator that is activated in times of reduced energy availability (high cellular AMP:ATP ratios) and serves to inhibit anabolic processes. In vivo, pharmacologic activation of AMPK with AICAR mimics exercise and triggers independent glucose uptake by skeletal muscle.

Cell-permeable, allosteric activator of AMP-activated protein kinase (AMPK). Augments proliferation, differentiation and mineralization of osteoblastic MC3T3-EI cells and attenuates psychosine-induced expression of proinflammatory cytokines and iNOS in astrocytes. Promotes osteogenic differentiation of hAMSCs and BM-MSCsin vitro. 

Specification:
Item Specification Result
Appearance White powder Complies
Related substance (HPLC) Total impurity ≤0.5%
Max single impurity ≤0.1%		 0.2%
0.06%
Odor Characteristic Complies
Assay 99% 99.8%
Sieve analysis 100% pass 80 mesh Complies
Loss on Drying
Residue on Ignition		 ≤1.0%
≤1.0%		 0.12%
0.09%
Heavy Metal <10ppm Complies
As <0.1ppm 0.05ppm
Pb <0.1ppm 0.05ppm
Cd <0.1ppm 0.05ppm
Residual Solvents <100ppm Complies
Residual Pesticide Negative Complies
Microbiology    
Total Plate Count <1000cfu/g Complies
Yeast & Mold <100cfu/g Complies
E.Coli Negative Complies
Salmonella Negative Complies

Chemical Properties Solid 

Usage glucose uptake stimulant; AMPK activator 
Usage AICAR is a nucleoside analogue that is able to enter nucleoside pools and is able to significantly increase levels of adenosine during periods of ATP breakdown. Adenosine-regulating agents (ARAs) hav e been recognized for therapeutic potential in myocardial ischemia. Cardioprotective. 
Biological Activity Cellpermeable, allosteric activator of AMPactivated protein kinase (AMPK). Augments proliferation, differentiation and mineralization of osteoblastic MC3T3-EI cells and attenuates psychosine-induced expression of proinflammatory cytokines and iNOS in astrocytes. 


**********************************************************************************
Payment method: Escrow, Western Union, Paypal, TT, L/C.
Shipping method: Fedex, DHL, EMS or by SEA
Delivery time: within 3days after payment, 7-10days to arrive.
*********************************************************************************

We have following SARMS series:
SARMs NUM SARMs Name SARMs CAS No
SARMs1 LGD-4033 1165910-22-4
SARMs2 MK-2866 1202044-20-9
SARMs3 MK-677 1132656-73-5
SARMs4 GW-501516 317318-70-0
SARMs5 AICAR  2627-69-2
SARMs6 SR9009 1379686-30-2
SARMs7 RAD140 1182367-47-0
SARMs8 Andarine(S4) 401900-40-1


Contact Methods:
http://www.czgpharmacy.com/
Miss. Lily
SKY==P=E: live:bettyleena
Tel: +86-18861115103
+86 0519 86879655
Fax:+86 0519 86474295

We also have (powder, injection and oral pills), peptides and Hormone products.
If you have any iuquiry, you can contact me!!! SARM Aicar Acadesine CAS 2627-69-2 Sarms Powder Acadesine Aicar

Aicar Details:

Name:Aicar
Synonyms:Acadesine;Aica-riboside;Ampk;5-aminoimidazole-4-carboxamide-1-beta-riboside;
5-aminoimidazole-4-carboxamide-1-b-d-ribofuranoside;Z-riboside
CAS: 2627-69-2
MF: C9H14N4O5
MW: 258.23
EINECS: 220-097-5
Chemical Properties:white or off-white solid
Assay:99%
Usage:glucose uptake stimulant; AMPK activator.AICAR is a nucleoside analogue that is able to enter nucleoside pools and is able to significantly increase levels of adenosine during periods of ATP breakdown. Adenosine-regulating agents (ARAs) hav e been recognized for therapeutic potential in myocardial ischemia. Cardioprotective.
Packing:foil bag or as required

Description:

AICAR is a peptide whose technical name is 5-Aminoimidazole-4-carboxamide ribonucleotide.  It can also be known as AICA ribonucleotide, ZMP, or Acadesine.  It is an intermediate contained in the generation of inosine monophosphate.  It primarily functions as an AMP-activated protein kinase agonist, meaning that it has the ability to promote the operation of nutrient stores for energy production.  It has a molecular mass of 338.211, and it has a molecular formula of C9H15N4O8P.

AICAR is an adenosine analog that selectively activates AMP-activated protein kinase (AMPK). AMPK regulates lipid and glucose metabolism to maintain cellular energy homeostasis (Hardie and Carling).

AICAR can play a hand in boosting these processes because it contains the ability to penetrate cardiac cells and block the production of enzymes tied to regulating glucose intake and energy expulsion.  With these regulatory enzymes inhibited, the affected cells can in turn boost the amount of glucose that can be received, and it can also increase its level of energy conversion.  Additionally, the peptide's presence has been determined to aid in lowering programmed cell death, a process that is also known as apoptosis.

Functions:

AICAR (AICA-Riboside) strongly inhibits the transcription of PPAR&alpha and the coactivation of PPAR&alpha. In adipocyte studies it has been shown to antagonize lipolysis induced by isoprenaline and has been suggested for use in kinase cascade research. Additionally, research indicates that AICAR blocks the differentiation of 3T3-L1 (sc-2243) adipocytes. Studies demonstrate that AICAR can mimic the activity of  (sc-211647) by activating AMPK (AMP-activated protein kinase), and affecting the expression of PEPCK-M (PEPCK) and glucose-6-phosphatase (G6Pase). The 5-aminoimidazole-4-carboxamide ribonucleoside (ZMP) is the monophosphorylated derivative of AICA-Riboside, and it can serve as the substrate for the aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC). AICAR is an inhibitor of Hsp90, mTOR and p70 S6 Kinase.

AMP-activated protein kinase (AMPK) functions as a metabolic sensor that regulates lipid and glucose metabolism to maintain cellular energy homeostasis and to protect against metabolic stress.AICAR is a selective activator of AMPK in both hepatocytes and adipocytes. At 0.5 mM it inhibits the synthesis of fatty acids and sterols and inactivates HMG-CoA reductase in rat hepatocytes.AICAR (0.5 mM) inhibits stimulated glucose uptake to 62% of controls and reduces GLUT4 translocation 2.5-fold in 3T3-L1 adipocytes. It also blocks the expression of pro-inflammatory cytokines (TNF-α/IL-1β and IL-6), iNOS, COX-2, and MnSOD genes in glial cells and macrophages by inhibiting NFκB and C/EBP pathways.

Biological Activity:

AICAR is a cell permeable activator of AMP-activated protein kinase (AMPK), a metabolic master regulator that is activated in times of reduced energy availability (high cellular AMP:ATP ratios) and serves to inhibit anabolic processes. In vivo, pharmacologic activation of AMPK with AICAR mimics exercise and triggers independent glucose uptake by skeletal muscle.

Cell-permeable, allosteric activator of AMP-activated protein kinase (AMPK). Augments proliferation, differentiation and mineralization of osteoblastic MC3T3-EI cells and attenuates psychosine-induced expression of proinflammatory cytokines and iNOS in astrocytes. Promotes osteogenic differentiation of hAMSCs and BM-MSCsin vitro. 

Specification:
Item Specification Result
Appearance White powder Complies
Related substance (HPLC) Total impurity ≤0.5%
Max single impurity ≤0.1%		 0.2%
0.06%
Odor Characteristic Complies
Assay 99% 99.8%
Sieve analysis 100% pass 80 mesh Complies
Loss on Drying
Residue on Ignition		 ≤1.0%
≤1.0%		 0.12%
0.09%
Heavy Metal <10ppm Complies
As <0.1ppm 0.05ppm
Pb <0.1ppm 0.05ppm
Cd <0.1ppm 0.05ppm
Residual Solvents <100ppm Complies
Residual Pesticide Negative Complies
Microbiology    
Total Plate Count <1000cfu/g Complies
Yeast & Mold <100cfu/g Complies
E.Coli Negative Complies
Salmonella Negative Complies

Chemical Properties Solid 

Usage glucose uptake stimulant; AMPK activator 
Usage AICAR is a nucleoside analogue that is able to enter nucleoside pools and is able to significantly increase levels of adenosine during periods of ATP breakdown. Adenosine-regulating agents (ARAs) hav e been recognized for therapeutic potential in myocardial ischemia. Cardioprotective. 
Biological Activity Cellpermeable, allosteric activator of AMPactivated protein kinase (AMPK). Augments proliferation, differentiation and mineralization of osteoblastic MC3T3-EI cells and attenuates psychosine-induced expression of proinflammatory cytokines and iNOS in astrocytes. 


**********************************************************************************
Payment method: Escrow, Western Union, Paypal, TT, L/C.
Shipping method: Fedex, DHL, EMS or by SEA
Delivery time: within 3days after payment, 7-10days to arrive.
*********************************************************************************

We have following SARMS series:
SARMs NUM SARMs Name SARMs CAS No
SARMs1 LGD-4033 1165910-22-4
SARMs2 MK-2866 1202044-20-9
SARMs3 MK-677 1132656-73-5
SARMs4 GW-501516 317318-70-0
SARMs5 AICAR  2627-69-2
SARMs6 SR9009 1379686-30-2
SARMs7 RAD140 1182367-47-0
SARMs8 Andarine(S4) 401900-40-1


Contact Methods:
http://www.czgpharmacy.com/
Miss. Lily
SKY==P=E: live:bettyleena
Tel: +86-18861115103
+86 0519 86879655
Fax:+86 0519 86474295

We also have (powder, injection and oral pills), peptides and Hormone products.
If you have any iuquiry, you can contact me!!!

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