Reconstruction plan: improve the stability of liquid preparation (oral liquid) production line

1 question raised

The liquid preparation workshop of Chengdu Sanle Pulp Group Sichuan Huamei Pharmaceutical Co., Ltd. has two 30mL liquid preparation production lines, which are mainly used for oral liquid production. The production line consists of a horizontal bottle washer, a sterilization drying oven and a filling machine with a designed production capacity of 180 pieces/min. In the operation of the production line, the stability and interface of each process equipment play a vital role in the production efficiency of the production line. However, in actual production, the production efficiency of the assembly line can only reach 70% of the design capacity, which increases the production cost and increases the working time. After actual analysis, it was found that the main reason for the low productivity was that the “breaking bottle” caused by the unreasonable bottle-wound wheel and the metering pump of the filling machine were unstable.

2 problem solving

2.1 The problem of bottle breaking machine "broken bottle"

During the maintenance, we carried out a comprehensive inspection of the bottle washing machine and found that all parts of the bottle washing machine are in good condition, and the matching of the parts is no problem, but the "broken bottle" failure still occurs frequently.

After careful observation, I finally found the root cause of the problem. It turned out that the bottle glass from the bottle dial to the sterilization oven platform was too large, which caused the load of the bottle wheel to increase, which caused the chuck and the bottle wheel to be misaligned. bottle". Why is there a heavy load on the track and platform of just 1m? From the structural point of view, the two sides of the track are composed of U-shaped stainless steel embedded with nylon strips. The track is a stainless steel strip with a thickness of 20 mm and a width of 12 mm. The oven platform consists of a stainless steel plate of about 0.65 m2. This kind of structure will not cause too much resistance to the glass bottle. We will fill the glass bottle with the glass bottle without the cleaning and the oven platform, and push the glass bottle at the bottle wheel to find that it can be glassed with only a little force. Bottle push. In addition, we cleaned these glass bottles and then covered the track and oven platform. We pushed the glass bottles by hand and found that the resistance increased significantly. So we found that the glass bottle and stainless steel surface were caused by the water flowing on the metal surface and the water pressure. The adsorption force is generated, and the resistance of the glass bottle is increased, thereby causing the bottle washer to malfunction and importing the pump.

After research, we have supplemented a layer of polytetrafluoroethylene plate on the track and platform, using the lower friction coefficient of polytetrafluoroethylene and the good fluidity of water to alleviate the resistance of the glass bottle. Through production verification, this method completely solves the problem that the bottle washing machine is easy to “break the bottle” and reduces the number of times the bottle washing machine is stopped.

2.2 Solution of metering pump metering instability problem

There are 12 sets of filling machine metering pumps. Any problem with the metering pump will cause the equipment to stop. How to increase the stability of the metering pump is the key to solving the shortage of filling machine capacity. At the time, our production line was designed and manufactured in the range of 30 to 100 mL. At the time, the metering range of the metering pump provided by the manufacturer was 20 to 100 mL. The diameter of the metering cylinder was large, which easily caused measurement deviation, and because the piston used polytetrafluoroethylene at that time. The machining accuracy is deviated, and the piston wears faster, causing dripping and liquid leakage, which causes the filling machine to stop frequently.

Later, the manufacturer repurchased a set of metering pumps with small metering cylinders, which were dedicated to the 30mL specification. However, the new metering pump still wears faster in the use of the PTFE piston, which affects the stability of the equipment. Therefore, we have carried out the piston part. Small changes to increase the stability of the metering pump.

Before the transformation, the piston is installed on the piston rod by two PTFE V-type seals, and is sealed by the rear edge of the PTFE V-type (as shown in Figure 1). The material of the PTFE is not wear-resistant and elastic. Poor, the V-shaped rear edge of the piston is easy to wear, causing metering deviation, and only the piston can be replaced at the stop, and the processing precision of the piston is high, the processing cost is high, and the maintenance cost is increased.

During the retrofitting, we used the worn polytetrafluoro piston to cut off the V-shaped trailing edge, leaving only the cylindrical portion. According to the diameter of the cylinder, the silicone pad is made, and then the two pieces of PTFE cylinder are used to sandwich the silicone. The piston rod fastening bolts are properly tightened (as shown in Figure 2), and sealed by the sealing characteristics of the silicone pad to achieve durability. The purpose of the seal. This modification increases the wear resistance of the piston, reduces the number of equipment downtimes, and the silicone pad is easy to process and low in cost.

2.3 Out of the bottle dial

The finished product from the filling machine is sent to the sterilization workshop for sterilization through the conveyor belt, and any failure of the middle equipment will affect the production capacity. Because the bottle filling wheel of the original filling machine is designed to use the impact type (as shown in Figure 3), the glass bottle is easily broken, causing the liquid to leak and contaminate the conveyor belt, resulting in downtime, and the noise caused by the impact. The operator is very uncomfortable.

In response to this problem, we will carry out technical transformation of the bottle wheel, which is to increase the diameter of the bottle wheel and the other dimensions are unchanged, and then cut along each bottle groove arc (as shown in Figure 4). After this transformation, the bottle is squeezed by the protruding part to greatly reduce the impact force between the bottle and the bottle. The glass bottle is naturally intact, reducing the number of downtimes and improving the working environment of the operator.

3 Conclusion

After the above-mentioned series of technical transformations, the stability of the 30mL liquid preparation production line has been significantly improved, basically achieving the design production capacity of the production line, and greatly reducing the production cost.

It can be considered that for the maintenance of the equipment, it is not only necessary to look at the fault surface, but to grasp the working principle of the equipment, analyze the fault, and find out the crux of the fault, so that the problem can be completely solved. At the same time, the defects of the equipment can not be ignored, but must be carefully analyzed, put forward an effective technical transformation program, and carry out technical transformation, in order to reduce the equipment failure rate, thereby improving the stability of the equipment.

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